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The UK's National Health Service (NHS) is planning a trial this March of an implant that can directly affect brain activity and improve patients' moods, The Guardian reports.
The implant, developed by US organization Forest Neurotech, is placed under the skull but does not penetrate the brain. It reads the activity of neurons and acts on them with focused ultrasound to help adjust brain function.
The safety and tolerability of the implant will be tested on 30 patients in a £6.5 million trial funded by the UK's Advanced Research and Invention Agency. Participants will be patients who have had part of their skull temporarily removed following brain injury. This will allow the device to be tested without the need for additional surgery.
The developers hope the implant will help treat depression, epilepsy, obsessive-compulsive disorder and addictions, especially in patients who are not helped by traditional methods.
“Up to a third of patients with depression or epilepsy do not respond to treatment. For such people, this technology could be life-changing,” said neurosurgeon Aymun Jamjum, who is leading the project.
During testing, the device will be placed on the participants' scalp at the site of the skull defect. For two hours, researchers will measure brain activity and see if it can be used to improve mood and motivation. The main difficulty is related to the heating of brain tissue due to ultrasound. Scientists are working to minimize this problem. In addition, it is important that the technology does not cause undesirable changes, for example, in a person's personality.
If the tests are successful, the developers plan to move on to full-fledged clinical trials to use the device in the treatment of depression and other diseases.