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A novel male contraceptive gel combining two hormones, segesterone acetate—named Nestorone—and testosterone, suppresses sperm production faster than similar experimental hormone-based methods for male birth control, according to a new study, reports Medical Xpress.
According to senior researcher Diana Blithe, Ph.D., chief of the Contraceptive Development Program at the National Institutes of Health (NIH) in Bethesda, Maryland, USA, testosterone treatment alone decreases sperm production, with a median time of 15 weeks but the addition of segesterone acetate speeds the time and lowers the dose of testosterone needed to suppress sperm production over testosterone alone.
In the daily segesterone-testosterone gel regimen, blood levels of testosterone are kept in the physiologic range to maintain normal sexual function and other androgen-dependent activities.
The sperm suppression stage of the international phase 2b trial of segesterone-testosterone gel is complete. The study continues to test the contraceptive's effectiveness, safety, acceptability and reversibility of contraception after treatment stops.