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Researchers from Queen Mary University of London and the Norwegian School of Sports Sciences have found that seven-day fasting effectively changes the body's fat-burning regime and causes changes in proteins important for brain function. The findings of the study were published in the journal Nature Metabolism.
Twelve healthy volunteers who drank only water for a week participated in the study. Researchers analyzed the changes of about three thousand proteins in the participants’ bloods before, during, and after the experiment.
Within 48-72 hours, the participants' bodies switched from using glucose to breaking down fat as the main source of energy. Participants lost an average of 5.7 kilograms in seven days. But after returning to a nutritious diet, their muscle mass was fully restored within three days, while fat levels remained low.
The researchers looked specifically at changes in proteins that affect the functioning of major organs, including the brain. They began after the third day of starvation and were not associated with weight loss.
Maik Pietzner, a professor at Berlin Institute of Health at Charité, recalled the long history of fasting in the treatment of various diseases, such as epilepsy and arthritis. But he emphasized the need to find alternatives for people for whom fasting is contraindicated.