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Chinese scientists from the Fourth Military Medical University in Xi'an have performed the first experimental liver transplantation of a genetically modified pig to a patient in irreversible coma. The study was published in the scientific journal Nature. The organ was taken from a miniature pig with six edited genes. The recipient was an adult with a diagnosed irreversible loss of brain function, whose life was kept alive with the help of medical devices.
The experiment lasted 10 days and was terminated at the request of the subject's family. Throughout the observation period, the transplanted liver functioned normally, producing bile and albumin protein.
Pigs are considered optimal donors for xenotransplants (organ transplants between species). Their anatomy and physiology are close to those of humans, and gene modification reduces the risk of rejection.
The study authors added that the pig liver produces much less bile and albumin compared to the human liver. New experiments lasting more than 10 days will be needed to improve the technology.