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American scientists from the University of Pennsylvania have developed an innovative biomaterial capable of mimicking the behavior of living tissues. This compound, called LivGels, can reproduce the mechanical reactions of extracellular matrices (ECM) - the structures that support cells and tissues in the body. The findings are published in the journal Materials Horizons (MatHor).
LivGels are created from biological components, including modified alginate (a polysaccharide from brown algae) and nanocrystals with cellulose “hairs.” The elements form dynamic bonds that allow the material to mimic the key properties of VCM: nonlinear hardening and regeneration.
Nonlinear hardening makes the material stiffer under mechanical forces, while regeneration enables it to recover from damage.
“Our material dynamically mimics the behavior of extracellular matrices, making it ideal for regenerative medicine and other applications,” explained Amir Sheikhi, lead author of the study.
LivGels opens up new opportunities in the fields of regenerative medicine, disease modeling, 3D bioprinting and soft robotics.
The researchers plan to optimize LivGels for specific tissue types, explore its application in regenerative medicine and integrate it with 3D bioprinting technologies. They are also considering the possibility of using the material in wearable devices and implants.