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A major breakthrough has been made in the field of medical diagnostics. South Korean scientists have made it possible to diagnose cervical cancer and analyze its microbiome from a single sample. Traditionally, these objectives required separate procedures, but a recent study has shown a more efficient and faster approach, reports Korea Biomedical Review.
The study, led by Professor Kim Dong Ki of Seoul National University Bundang Hospital and Professor Kim Dong Kyu of Chung-Ang University, examined the potential of liquid-based cytology (LBC) samples for two purposes.
LBC is a modern method for screening for cervical cancer in which cells collected from the cervix are preserved in a liquid medium, which increases the preservation of cells and diagnostic accuracy compared to traditional methods. The researchers analyzed the microbial communities of 30 women, comparing LBC samples to traditional samples.
The results showed that LBC samples provided microbiome data comparable to samples with similar proportions of key bacteria, particularly Lactobacillus and Gardnerella. The scientists found that LBC samples showed higher microbial diversity, suggesting that they may be more suitable for comprehensive microbial analysis, according to the study published in the journal PLOS One.
This development is particularly important given the role of the cervical microbiome in women's health. A healthy cervix is mainly populated by beneficial bacteria, particularly Lactobacillus, which help protect against infections. However, increased microbial diversity and the presence of specific pathogenic bacteria were associated with an increased risk of developing HPV infection and the progression of cervical lesions. Therefore, analysis of its microbiome, along with cancer screening, can provide a more complete picture of a dependent's health and potential risks.
The authors of the study note that integrating microbiome analysis into routine cervical cancer screening using LBC specimens offers promising opportunities for early detection and personalized treatment strategies. By using a single specimen for cytology and microbiological evaluation, healthcare providers can obtain comprehensive information without subjecting caregivers to multiple procedures.
This approach not only simplifies the diagnostic process, but also opens up opportunities for the development of novel biomarkers for early cancer detection.
Thus, the ability to obtain important information about both cellular abnormalities and microbial composition from a single LBC specimen is a significant advance in caregiver diagnosis.