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Researchers at George Mason University in the US, together with colleagues from China, have found that the risk of developing type 2 diabetes among depressed patients is not related to this disease, but to the intake of antidepressants. The findings of their study were published in the journal Progress in Neuro-Psychopharmacology & Biological Psychiatry.
Using Mendelian randomization (MR) to analyze the genetic data, these researchers found that genes associated with depression did not increase the risk of diabetes. But among patients taking antidepressants, two genetic segments found on chromosomes 14 and 17 increase the likelihood of developing this disease. These segments were called antidepressant drug genes.
The researchers explained that the risk of diabetes among depressed patients not taking antidepressants remained at the average level of the population. In turn, those who undergo long-term drug therapy are quite prone to this disease, which requires careful monitoring of metabolic indicators.
Researchers emphasize the need to develop individualized approaches to prescribing antidepressants to reduce potential negative health outcomes for patients.